Mouse oocytes control metabolic co-operativity between oocytes and cumulus cells
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چکیده
منابع مشابه
Mouse oocytes control metabolic co-operativity between oocytes and cumulus cells.
Precise coordination between the development of the oocyte and the ovarian follicle is essential in order to provide an egg that is fully competent to undergo fertilisation and embryo development. A key component of this co-ordination is changing patterns of gene expression and protein synthesis by various populations of granulosa cells throughout follicular development. There are two populatio...
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Oocyte-derived bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are key regulators of follicular development. Here we show that these factors control cumulus cell metabolism, particularly glycolysis and cholesterol biosynthesis before the preovulatory surge of luteinizing hormone. Transcripts encoding enzymes for cholesterol biosynthesis were downregulated in bot...
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A search for genes expressed more highly in mouse cumulus cells than mural granulosa cells by subtraction hybridization yielded Slc38a3. SLC38A3 is a sodium-coupled neutral amino acid transporter having substrate preference for l-glutamate, l-histidine, and l-alanine. Detectable levels of Slc38a3 mRNA were found by in situ hybridization in granulosa cells of large preantral follicles, but level...
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ژورنال
عنوان ژورنال: Reproduction, Fertility and Development
سال: 2005
ISSN: 1031-3613
DOI: 10.1071/rdv17n2paperabs